Brand name: methotrexate
Generic name: Rheumatrex, Emthexate, Methoblastin, MTX, amethopterin

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This indicates that NSAIDs may enhance the toxicity of methotrexate. No interference occurs, however, if methotrexate is measured by a radioimmunoassay (RIA). Alkalinization of urine (with bicarbonate and/or acetazolamide) and intravenous hydration (1000 mL per square meter of body surface area over six hours prior to beginning the methotrexate infusion and 3000 mL per square meter of body surface area per day during the methotrexate infusion and for two days after the infusion is completed) are also important to prevent renal toxicity caused by methotrexate and/or its metabolites. In patients receiving concomitant methotrexate, the incidence was 6% compared to 26% with Humira monotherapy. She had been successfully treated with infliximab 3 mg/kg every 6 to 8 weeks together with methotrexate, without side effects. Her RA had been treated with methotrexate (10 mg per week) and bucillamine (200 mg per day) for 6 years. Taking methotrexate and alcohol together may increase the risk of liver injury. Necrotizing fasciitis resulting in death has been reported in a 54-year-old man with rheumatoid arthritis receiving infliximab every 8 weeks along with intramuscular methotrexate weekly dosage.

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